Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.7/100
Título: Adaptive mutations in bacteria: high rate and small effects
Autor: Perfeito, L.
Fernandes, C.
Mota, G.
Isabel, G.
Palavras-chave: Adaptation, Biological
Escherichia coli/genetics/physiology
Genome, Bacterial
Selection, Genetic
Data: Ago-2007
Citação: Perfeito, L. Fernandes, C. Mota and I. Gordo (2007) Adaptive Mutations in Bacteria: High Rate and Small Effects. Science 317(5839):813-5
Resumo: Evolution by natural selection is driven by the continuous generation of adaptive mutations. We measured the genomic mutation rate that generates beneficial mutations and their effects on fitness in Escherichia coli under conditions in which the effect of competition between lineages carrying different beneficial mutations is minimized. We found a rate on the order of 10(-5) per genome per generation, which is 1000 times as high as previous estimates, and a mean selective advantage of 1%. Such a high rate of adaptive evolution has implications for the evolution of antibiotic resistance and pathogenicity.
URI: http://hdl.handle.net/10400.7/100
ISSN: 0036-8075
Aparece nas colecções:EB - Artigos

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