Instituto Gulbenkian de Ciência Fundação Calouste Gulbenkian

ARCA - IGC Repository >
Systems Neuroscience >
SN - Artigos >

Please use this identifier to cite or link to this item:

Título: A defined network of fast-spiking interneurons in orbitofrontal cortex: responses to behavioral contingencies and ketamine administration
Autor: Quirk, MC
Sosulski, DL
Feierstein, CE
Uchida, N
Mainen, ZF
Issue Date: 2009
Editora: Cold Spring Harbor
Citação: Quirk, Michael C., Sosulski, Dara L., Feierstein, Claudia E., Naoshige, U., Mainen, Zachary F. (2009). “A defined network of fast-spiking interneurons in orbitofrontal cortex: responses to behavioral contingencies and ketamine administration”. Frontiers in Systems Neuroscience. 3: 1-13
Resumo: Orbitofrontal cortex (OFC) is a region of prefrontal cortex implicated in the motivational control of behavior and in related abnormalities seen in psychosis and depression. It has been hypothesized that a critical mechanism in these disorders is the dysfunction of GABAergic interneurons that normally regulate prefrontal information processing. Here, we studied a subclass of interneurons isolated in rat OFC using extracellular waveform and spike train analysis. During performance of a goal-directed behavioral task, the firing of this class of putative fast-spiking (FS) interneurons showed robust temporal correlations indicative of a functionally coherent network. FS cell activity also co-varied with behavioral response latency, a key indicator of motivational state. Systemic administration of ketamine, a drug that can mimic psychosis, preferentially inhibited this cell class. Together, these results support the idea that OFC-FS interneurons form a critical link in the regulation of motivation by prefrontal circuits during normal and abnormal brain and behavioral states.
ISSN: 1662-5137
Appears in Collections:SN - Artigos

Files in This Item:

File Description SizeFormat
Fronties in systems neuroscience.pdf1,67 MBAdobe PDFView/Open

Please give feedback about this item
FacebookTwitterDeliciousLinkedInDiggGoogle BookmarksMySpaceOrkut
Formato BibTex mendeley Endnote Logotipo do DeGóis 

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.


Feedback - Statistics
Copyright © IGC - Instituto Gulbenkian de Ciência 2009
Promotores do RCAAP   Financiadores do RCAAP

Fundação para a Ciência e a Tecnologia Universidade do Minho   Governo Português Ministério da Educação e Ciência PO Sociedade do Conhecimento (POSC) Portal oficial da União Europeia