Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.7/213
Título: IgG autoantibody to brain beta tubulin III associated with cytokine cluster-II discriminate cerebral malaria in central India
Autor: Bansal, D.
Herbert, F.
Lim, P.
Deshpande, P.
Becavin, C.
Guiyedi, V.
de Maria, I.
Rousselle, J.C.
Namane, A.
Jain, R.
Cazenave, P.A.
Mishra, G.C.
Ferlini, C.
Fesel, C.
Benecke, A.
Pied, S.
Palavras-chave: Antigens, Protozoan/immunology
Autoantibodies/blood
Brain/immunology
Cytokines/blood
Immunoglobulin G/immunology
Immunoglobulin M/immunology
Data: Dez-2009
Editora: Public Library of Science
Citação: Bansal,D., Herbert,F., Lim,P., Deshpande,P., Becavin,C., Guiyedi,V., de Maria,I., Rousselle,J.C., Namane,A., Jain,R., Cazenave,P.A., Mishra,G.C., Ferlini,C., Fesel,C., Benecke,A., Pied,S.(2009). IgG Autoantibody to Brain Beta Tubulin III Associated with Cytokine Cluster-II Discriminate Cerebral Malaria in Central India. PLOS ONE, 4(12): 38245
Resumo: We investigated the significance of these self-reactive antibodies in clinically well-defined groups of P. falciparum infected patients manifesting mild malaria (MM), severe non-cerebral malaria (SM), or cerebral malaria (CM) and in control subjects from Gondia, a malaria epidemic site in central India using quantitative immunoprinting and multivariate statistical analyses. A two-fold complete-linkage hierarchical clustering allows classifying the different patient groups and to distinguish the CM from the others on the basis of their profile of IgG reactivity to brain proteins defined by PANAMA Blot. We identified beta tubulin III (TBB3) as a novel discriminant brain antigen in the prevalence of CM. In addition, circulating IgG from CM patients highly react with recombinant TBB3. Overall, correspondence analyses based on singular value decomposition show a strong correlation between IgG anti-TBB3 and elevated concentration of cluster-II cytokine (IFNγ, IL1β, TNFα, TGFβ) previously demonstrated to be a predictor of CM in the same population
Peer review: yes
URI: http://hdl.handle.net/10400.7/213
http://dx.doi.org/10.1371/journal.pone.0008245
ISSN: 1932-6203
Versão do Editor: http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0008245
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