Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.7/214
Título: Self-reactivities to the non-erythroid alpha spectrin correlate with cerebral malaria in Gabonese children
Autor: Guiyedi, V.
Chanseaud, Y.
Fesel, C.
Snounou, G.
Rousselle, J.C.
Lim, P.
Koko, J.
Namane, A.
Cazenave, P.A.
Kombila, M.
Pied, S.
Palavras-chave: Immunoglobulin G/immunology
Malaria, Cerebral/immunology
Malaria, Falciparum/immunology
Spectrin/immunology
Data: Abr-2007
Editora: Public Library of Science
Citação: Guiyedi, V, Chanseaud, Y., Fesel C., Snounou G., Rousselle J.-C., Lim P., Koko J., Namane A., Cazenave P.-A., Kombila M., Pied S. (2007) “Self-reactivities to the non-erythroid Alpha Spectrin correlate with cerebral malaria in Gabonese children”. PLOS One. 2(4): e389
Resumo: Hypergammaglobulinemia and polyclonal B-cell activation commonly occur in Plasmodium sp. infections. Some of the antibodies produced recognize self-components and are correlated with disease severity in P. falciparum malaria. However, it is not known whether some self-reactive antibodies produced during P. falciparum infection contribute to the events leading to cerebral malaria (CM). We show here a correlation between self-antibody responses to a human brain protein and high levels of circulating TNF alpha (TNFα), with the manifestation of CM in Gabonese children
Peer review: yes
URI: http://hdl.handle.net/10400.7/214
http://dx.doi.org/10.1371/journal.pone.0000389
ISSN: 1932-6203
Versão do Editor: http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0000389
Aparece nas colecções:LAIR articles

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