Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.7/254
Título: Early skin immunological disturbance after Plasmodium-infected mosquito bites
Autor: Silva, Henrique Borges da
Caetano, Susana S
Monteiro, Isadora
Gómez-Conde, Iván
Hanson, Kirsten
Penha-Gonçalves, Carlos
Olivieri, David N
Mota, Maria M
Marinho, Cláudio R.
D’Imperio Lima, Maria R.
Tadokoro, Carlos E
Data: 2012
Citação: Silva, Henrique Borges da; Caetano, Susana S; Monteiro, Isadora; Gómez-Conde, Iván; Hanson, Kirsten; Penha-Gonçalves, Carlos; Olivieri, David N; Mota, Maria M; Marinho, Cláudio R.; D’Imperio Lima, Maria R.; Tadokoro, Carlos E. Early skin immunological disturbance after Plasmodium-infected mosquito bites, Cellular Immunology, 277, 1-2, 22-32, 2012.
Resumo: Although the role of regulatory T cells (Tregs) during malaria infection has been studied extensively, such studies have focused exclusively on the role of Treg during the blood stage of infection; little is known about the detailed mechanisms of Tregs and sporozoite deposition in the dermis by mosquito bites. In this paper we show that sporozoites introduced into the skin by mosquito bites increase the mobility of skin Tregs and dendritic cells (DCs). We also show differences in MHC class II and/or CD86 expression on skin-resident dendritic cell subtypes and macrophages. From the observed decrease of the number of APCs into draining lymph nodes, suppression of CD28 expression in conventional CD4 T cells, and a low homeostatic proliferation of skin-migrated CD4 T found in nude mice indicate that Tregs may play a fundamental role during the initial phase of malaria parasite inoculation into the mammalian host
Peer review: Yes
URI: http://hdl.handle.net/10400.7/254
Versão do Editor: http://dx.doi.org/10.1016/j.cellimm.2012.06.003
Aparece nas colecções:DG - Artigos em revistas científicas

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