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We study how chromosome architecture contributes to faithful genome segregation. Genome stability relies on the fact that at each round of cell division, the genetic information encoded in the DNA molecules is properly segregated into the two daughter cells. Proper completion of this process, in turn, depends on two major changes in chromosome organization: 1) The two-sister DNA molecules remain tightly associated with each other from the moment of DNA replication until the later stages of the subsequent mitosis; 2) At the onset of nuclear division, chromatin is converted into compact structures with the right mechanical properties (size, flexibility, and rigidity) to facilitate their segregation; Our laboratory adopts a multidisciplinary approach, combining Drosophila genetics, acute protein inactivation, 4D-live cell imaging and biophysical/mathematical modelling to evaluate how dynamic mitotic chromosomes are assembled and how their morphology influences the mechanical aspects of chromosome movement and cell cycle checkpoint signalling. In parallel we aim to dissect how different cells respond to compromised chromosome cohesion and condensation, both at the cellular and organism level. By studying the contribution of chromosome structure in the mechanics of nuclear division we aim to identify novel routes to aneuploidy that underlie several human conditions, including developmental diseases, cancer and infertility. Informal enquiries on research or available positions in our group are welcome and should be sent to Raquel Oliveira. We welcome people from a range of backgrounds, including biology, biochemistry, chemistry, physics, biological engineering and bioinformatics.

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Items da Coleção (Ordenados por Data de depósito em ordem descendente): 1 até 8 de 8
6-Mai-2017Metaphase chromosome structure is dynamically maintained by condensin I-directed DNA (de)catenationPiskadlo, Ewa; Tavares, Alexandra; Oliveira, Raquel AarticleopenAccess
25-Jul-2016Novel insights into mitotic chromosome condensationPiskadlo, Ewa; Oliveira, Raquel A.articleopenAccess
22-Jul-2013Cohesin cleavage is insufficient for centriole disengagement in DrosophilaOliveira, Raquel A.; Nasmyth, KimarticleopenAccess
18-Jun-2013Dynamical Scenarios for Chromosome Bi-orientationZhang, Tongli; Oliveira, Raquel A.; Schmierer, Bernhard; Novák, BélaarticleopenAccess
22-Jan-2013Disengaging the Smc3/kleisin interface releases cohesin from Drosophila chromosomes during interphase and mitosisEichinger, Christian S; Kurze, Alexander; Oliveira, Raquel A; Nasmyth, KimarticleopenAccess
24-Mar-2015Manipulation of the Quorum Sensing Signal AI-2 Affects the Antibiotic-Treated Gut MicrobiotaThompson, Jessica Ann; Oliveira, Rita Almeida; Djukovic, Ana; Ubeda, Carles; Xavier, Karina BivararticleopenAccess
8-Out-2015Premature Sister Chromatid Separation Is Poorly Detected by the Spindle Assembly Checkpoint as a Result of System-Level FeedbackMirkovic, Mihailo; Hutter, Lukas H.; Novák, Béla; Oliveira, Raquel A.articleopenAccess
7-Out-2014Centromere-Independent Accumulation of Cohesin at Ectopic Heterochromatin Sites Induces Chromosome Stretching during AnaphaseOliveira, Raquel A.; Kotadia, Shaila; Tavares, Alexandra; Mirkovic, Mihailo; Bowlin, Katherine; Eichinger, Christian S.; Nasmyth, Kim; Sullivan, WilliamarticleopenAccess
Items da Coleção (Ordenados por Data de depósito em ordem descendente): 1 até 8 de 8