Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.7/317
Título: Modeling Malaria Infection and Immunity against Variant Surface Antigens in Príncipe Island, West Africa
Autor: Trovoada, Maria Jesus
Gonçalves, Lígia A.
Marinho, Cláudio R. F.
Turner, Louise
Hviid, Lars
Penha-Gonçalves, Carlos
Gomes, M. Gabriela M.
Palavras-chave: Malaria Infection
Immunity
Data: 10-Fev-2014
Editora: PLOS
Citação: Bandeiras C, Trovoada MJ, Gonçalves LA, Marinho CRF, Turner L, Hviid L, et al. (2014) Modeling Malaria Infection and Immunity against Variant Surface Antigens in Príncipe Island, West Africa. PLoS ONE 9(2): e88110. doi:10.1371/journal.pone.0088110
Resumo: After remarkable success of vector control campaigns worldwide, concerns about loss of immunity against Plasmodium falciparum due to lack of exposure to the parasite are relevant since an increase of severe cases in less immune individuals is expected. We present a mathematical model to investigate the impact of reducing exposure to the parasite on the immune repertoire against P. falciparum erythrocyte membrane protein 1 (PfEMP1) variants. The model was parameterized with data from Príncipe Island, West Africa, and applied to simulate two alternative transmission scenarios: one where control measures are continued to eventually drive the system to elimination; and another where the effort is interrupted after 6 years of its initiation and the system returns to the initial transmission potential. Population dynamics of parasite prevalence predict that in a few years infection levels return to the pre-control values, while the re-acquisition of the immune repertoire against PfEMP1 is slower, creating a window for increased severity. The model illustrates the consequences of loss of immune repertoire against PfEMP1 in a given setting and can be applied to other regions where similar data may be available.
Descrição: This deposit is composed by the main article plus the supplementary materials of the publication.
Peer review: yes
URI: http://hdl.handle.net/10400.7/317
DOI: 10.1371/journal.pone.0088110
10.1371/journal.pone.0088110
Versão do Editor: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0088110
Aparece nas colecções:CD - Artigos
DG - Artigos em revistas científicas

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Bandeiras_PlosOne_2014.pdfmain article582,66 kBAdobe PDFVer/Abrir
Bandeiras_PlosOne_2014_SM_Fig.S1.tifsupplementary material 1232,03 kBTIFFVer/Abrir
Bandeiras_PlosOne_2014_SM_Fig.S2.tifsupplementary material 2235,71 kBTIFFVer/Abrir
Bandeiras_PlosOne_2014_SM_Fig.S3.tifsupplementary material 3234,08 kBTIFFVer/Abrir
Bandeiras_PlosOne_2014_SM_Table_S1.pdfsupplementary material 4108,46 kBAdobe PDFVer/Abrir
Bandeiras_PlosOne_2014_SM_Table_S2.pdfsupplementary material 538,41 kBAdobe PDFVer/Abrir
Bandeiras_PlosOne_2014_SM_Text_S1.pdfsupplementary material 645,03 kBAdobe PDFVer/Abrir


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