Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.7/339
Título: Modelling the onset of senescence at the G1/S cell cycle checkpoint
Autor: Mombach, José CM
Bugs, Cristhian A
Chaouiya, Claudine
Palavras-chave: Signalling network
Logical modelling
Senescence
DNA-damage
Cell fate
Cell cycle checkpoint
Data: 27-Out-2014
Editora: BioMed Central
Resumo: DNA damage (single or double-strand breaks) triggers adapted cellular responses. These responses are elicited through signalling pathways, which activate cell cycle checkpoints and basically lead to three cellular fates: cycle arrest promoting DNA repair, senescence (permanent arrest) or cell death. Cellular senescence is known for having a tumour-suppressive function and its regulation arouses a growing scientific interest. Here, we advance a qualitative model covering DNA damage response pathways, focusing on G1/S checkpoint enforcement, supposedly more sensitive to arrest than G2/M checkpoint.
Peer review: yes
URI: http://hdl.handle.net/10400.7/339
DOI: 10.1186/1471-2164-15-S7-S7
10.1186/1471-2164-15-S7-S7
Versão do Editor: http://www.biomedcentral.com/1471-2164/15/S7/S7
Aparece nas colecções:NM- Artigos

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