Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.7/341
Título: Symbionts commonly provide broad spectrum resistance to viruses in insects: a comparative analysis of Wolbachia strains
Autor: Martinez, Julien
Longdon, Ben
Bauer, Simone
Chan, Yuk-Sang
Miller, Wolfgang J
Bourtzis, Kostas
Teixeira, Luis
Jiggins, Francis M
Palavras-chave: Wolbachia
Drosophila
Dengue virus
Microbial Genetics
Data: 18-Set-2014
Editora: PLOS
Citação: Martinez J, Longdon B, Bauer S, Chan Y-S, Miller WJ, Bourtzis K, et al. (2014) Symbionts Commonly Provide Broad Spectrum Resistance to Viruses in Insects: A Comparative Analysis of Wolbachia Strains. PLoS Pathog 10(9): e1004369. doi:10.1371/journal.ppat.1004369
Resumo: In the last decade, bacterial symbionts have been shown to play an important role in protecting hosts against pathogens. Wolbachia, a widespread symbiont in arthropods, can protect Drosophila and mosquito species against viral infections. We have investigated antiviral protection in 19 Wolbachia strains originating from 16 Drosophila species after transfer into the same genotype of Drosophila simulans. We found that approximately half of the strains protected against two RNA viruses. Given that 40% of terrestrial arthropod species are estimated to harbour Wolbachia, as many as a fifth of all arthropods species may benefit from Wolbachia-mediated protection. The level of protection against two distantly related RNA viruses--DCV and FHV--was strongly genetically correlated, which suggests that there is a single mechanism of protection with broad specificity. Furthermore, Wolbachia is making flies resistant to viruses, as increases in survival can be largely explained by reductions in viral titer. Variation in the level of antiviral protection provided by different Wolbachia strains is strongly genetically correlated to the density of the bacteria strains in host tissues. We found no support for two previously proposed mechanisms of Wolbachia-mediated protection--activation of the immune system and upregulation of the methyltransferase Dnmt2. The large variation in Wolbachia's antiviral properties highlights the need to carefully select Wolbachia strains introduced into mosquito populations to prevent the transmission of arboviruses.
Peer review: yes
URI: http://hdl.handle.net/10400.7/341
DOI: 10.1371/journal.ppat.1004369
10.1371/journal.ppat.1004369
Versão do Editor: http://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1004369
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