Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.7/374
Título: Transcriptional control of vertebrate neurogenesis by the proneural factor Ascl1
Autor: Vasconcelos, Francisca F.
Castro, Diogo S.
Palavras-chave: Ascl1/Mash1
neurogenesis
proneural gene
transcription
Notch signaling
Data: 2-Dez-2014
Editora: Frontiers Research Foundation
Resumo: Proneural transcription factors (TFs) such as Ascl1 function as master regulators of neurogenesis in vertebrates, being both necessary and sufficient for the activation of a full program of neuronal differentiation. Novel insights into the dynamics of Ascl1 expression at the cellular level, combined with the progressive characterization of its transcriptional program, have expanded the classical view of Ascl1 as a differentiation factor in neurogenesis. These advances resulted in a new model, whereby Ascl1 promotes sequentially the proliferation and differentiation of neural/stem progenitor cells. The multiple activities of Ascl1 are associated with the activation of distinct direct targets at progressive stages along the neuronal lineage. How this temporal pattern is established is poorly understood. Two modes of Ascl1 expression recently described (oscillatory vs. sustained) are likely to be of importance, together with additional mechanistic determinants such as the chromatin landscape and other transcriptional pathways. Here we revise these latest findings, and discuss their implications to the gene regulatory functions of Ascl1 during neurogenesis.
Peer review: yes
URI: http://hdl.handle.net/10400.7/374
DOI: 10.3389/fncel.2014.00412
Versão do Editor: http://journal.frontiersin.org/article/10.3389/fncel.2014.00412/abstract
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