Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.7/385
Título: Control of Disease Tolerance to Malaria by Nitric Oxide and Carbon Monoxide
Autor: Jeney, Viktória
Ramos, Susana
Bergman, Marie-Louise
Bechmann, Ingo
Tischer, Jasmin
Ferreira, Ana
Oliveira-Marques, Virginia
Janse, Chris J.
Rebelo, Sofia
Cardoso, Silvia
Soares, Miguel P.
Palavras-chave: Malaria Infection
Nitric Oxide
Data: 10-Jul-2014
Editora: Cell Press
Resumo: Nitric oxide (NO) and carbon monoxide (CO) are gasotransmitters that suppress the development of severe forms of malaria associated with Plasmodium infection. Here, we addressed the mechanism underlying their protective effect against experimental cerebral malaria (ECM), a severe form of malaria that develops in Plasmodium-infected mice, which resembles, in many aspects, human cerebral malaria (CM). NO suppresses the pathogenesis of ECM via a mechanism involving (1) the transcription factor nuclear factor erythroid 2-related factor 2 (NRF-2), (2) induction of heme oxygenase-1 (HO-1), and (3) CO production via heme catabolism by HO-1. The protection afforded by NO is associated with inhibition of CD4(+) T helper (TH) and CD8(+) cytotoxic (TC) T cell activation in response to Plasmodium infection via a mechanism involving HO-1 and CO. The protective effect of NO and CO is not associated with modulation of host pathogen load, suggesting that these gasotransmitters establish a crosstalk-conferring disease tolerance to Plasmodium infection.
Peer review: yes
URI: http://hdl.handle.net/10400.7/385
DOI: 10.1016/j.celrep.2014.05.054
Versão do Editor: http://www.sciencedirect.com/science/article/pii/S2211124714004483
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