Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.7/386
Título: The evolution of metazoan α-carbonic anhydrases and their roles in calcium carbonate biomineralization
Autor: Le Roy, Nathalie
Jackson, Daniel J
Marie, Benjamin
Ramos-Silva, Paula
Marin, Frédéric
Palavras-chave: α -Carbonic anhydrase
Molecular evolution
Low complexity domains (LCDs)
Repetitive low complexity domains (RLCDs)
Data: 17-Out-2014
Editora: BioMed Central
Citação: Le Roy et al. : The evolution of metazoan α -carbonic anhydrases and their roles in calcium carbonate biomineralization. Frontiers in Zoology 2014 11 :75.
Resumo: The carbonic anhydrase (CA; EC superfamily is a class of ubiquitous metallo-enzymes that catalyse the reversible hydration of carbon dioxide. The ?-CA family, present in all metazoan clades, is a key enzyme involved in a wide range of physiological functions including pH regulation, respiration, photosynthesis, and biocalcification. This paper reviews the evolution of the ?-CA family, with an emphasis on metazoan ?-CA members involved in biocalcification. Phylogenetic analyses reveal a complex evolutionary history of ?-CAs, and suggest ?-CA was independently co-opted into a variety of skeleton forming roles (e.g. as a provider of HCO3? ions, a structural protein, a nucleation activator, etc.) in multiple metazoan lineages. This evolutionary history is most likely the result of multiple gene duplications coupled with the insertion of repetitive or non-repetitive low-complexity domains (RLCDs/LCDs). These domains, of largely unknown function, appear to be lineage-specific, and provide further support for the hypothesis of independent recruitment of ?-CAs to diverse metazoan biocalcification processes. An analysis of ?-CA sequences associated with biocalcification processes indicates that the domains involved in the activity and conformation of the active site are extremely conserved among metazoans.
Peer review: yes
URI: http://hdl.handle.net/10400.7/386
DOI: 10.1186/s12983-014-0075-8
Versão do Editor: http://www.frontiersinzoology.com/content/11/1/75
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