Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.7/397
Título: The importance of iron in pathophysiologic conditions
Autor: Gozzelino, Raffaella
Arosio, Paolo
Palavras-chave: iron
iron metabolism
iron and genetic disorders
iron deficiency and anemia
iron and inflammation
iron and cardiotoxicity
iron and neurodegeneration
heme iron
Data: 24-Fev-2015
Editora: Frontiers Research Foundation
Citação: Gozzelino R and Arosio P (2015) The importance of iron in pathophysiologic conditions. Front. Pharmacol. 6:26. doi: 10.3389/fphar.2015.00026
Resumo: Biological iron is necessary for vital functions and also potentially toxic to the organisms. This dual effect raised the interest of many investigators to study the mechanisms controlling its homeostasis that are altered in many pathologic conditions. Recently the understanding of iron metabolism significantly improved with the discovery of genes responsible for genetic disorders, such as hemochromatosis, the IRE/IRPs machinery and the hepcidin-ferroportin axis, which allowed to elucidate the basis of cellular and systemic iron homeostasis. In addition, these advances disclosed a causal link between deregulation of iron homeostasis, inflammation and oxidative stress, often induced by the iron accumulation that is commonly observed in many pathologic conditions.
Peer review: yes
URI: http://hdl.handle.net/10400.7/397
DOI: 10.3389/fphar.2015.00026
Versão do Editor: http://journal.frontiersin.org/article/10.3389/fphar.2015.00026/full
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