Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.7/412
Título: How Inflammation Impinges on NAFLD: A Role for Kupffer Cells
Autor: Duarte, Nádia
Coelho, Inês C.
Patarrão, Rita S.
Almeida, Joana I.
Penha-Gonçalves, Carlos
Macedo, M. Paula
Palavras-chave: Non-alcoholic Fatty Liver Disease
Kupffer Cells
Data: 5-Mar-2015
Editora: Hindawi Publishing Corporation
Citação: Nádia Duarte, Inês C. Coelho, Rita S. Patarrão, Joana I. Almeida, Carlos Penha-Gonçalves, and M. Paula Macedo, “How Inflammation Impinges on NAFLD: A Role for Kupffer Cells,” BioMed Research International, vol. 2015, Article ID 984578, 11 pages, 2015. doi:10.1155/2015/984578
Resumo: Nonalcoholic fatty liver disease (NAFLD) is rapidly becoming the most prevalent cause of liver disease worldwide and afflicts adults and children as currently associated with obesity and insulin resistance. Even though lately some advances have been made to elucidate the mechanism and causes of the disease much remains unknown about NAFLD. The aim of this paper is to discuss the present knowledge regarding the pathogenesis of the disease aiming at the initial steps of NAFLD development, when inflammation impinges on fat liver deposition. At this stage, the Kupffer cells attain a prominent role. This knowledge becomes subsequently relevant for the development of future diagnostic, prevention, and therapeutic options for the management of NAFLD.
Peer review: yes
URI: http://hdl.handle.net/10400.7/412
DOI: 10.1155/2015/984578
Versão do Editor: http://www.hindawi.com/journals/bmri/2015/984578/
Aparece nas colecções:DG - Artigos em revistas científicas

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