Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.7/426
Título: Genome architecture is a selectable trait that can be maintained by antagonistic pleiotropy
Autor: Teresa Avelar, Ana
Perfeito, Lília
Gordo, Isabel
Godinho Ferreira, Miguel
Palavras-chave: Biological sciences
Data: 23-Ago-2013
Editora: Nature Publishing Group
Citação: Avelar, A. T. et al. Genome architecture is a selectable trait that can be maintained by antagonistic pleiotropy. Nat. Commun. 4:2235 doi: 10.1038/ncomms3235 (2013).
Resumo: Chromosomal rearrangements are mutations contributing to both within and between species variation; however their contribution to fitness is yet to be measured. Here we show that chromosomal rearrangements are pervasive in natural isolates of Schizosaccharomyces pombe and contribute to reproductive isolation. To determine the fitness effects of chromosome structure, we constructed two inversions and eight translocations without changing the coding sequence. We show that chromosomal rearrangements contribute to both reproductive success in meiosis and growth rate in mitosis with a strong genotype by environment interaction. These changes are accompanied by alterations in gene expression. Strikingly, we find several examples leading to antagonistic pleiotropy. Even though chromosomal rearrangements may have a deleterious effect during sexual reproduction, some compensate with a strong growth advantage in mitosis. Our results constitute the first quantification of fitness effects caused by de novo mutations that result in chromosomal rearrangement variation and suggest a mechanism for their maintenance in natural populations.
Peer review: yes
URI: http://hdl.handle.net/10400.7/426
DOI: 10.1038/ncomms3235
Versão do Editor: http://www.nature.com/ncomms/2013/130823/ncomms3235/full/ncomms3235.html
Aparece nas colecções:EB - Articles
TGS - Artigos

Ficheiros deste registo:
Ficheiro Descrição TamanhoFormato 
Avelar_A.T._Nat.Commun._(2013).pdfmain article570,16 kBAdobe PDFVer/Abrir

FacebookTwitterDeliciousLinkedInDiggGoogle BookmarksMySpace
Formato BibTex MendeleyEndnote 

Todos os registos no repositório estão protegidos por leis de copyright, com todos os direitos reservados.