Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.7/439
Título: Majority rules with random tie-breaking in Boolean gene regulatory networks
Autor: Chaouiya, Claudine
Ourrad, Ouerdia
Lima, Ricardo
Palavras-chave: Gene Regulatory Networks
Models, Genetic
Cell Cycle
Data: 26-Jul-2013
Editora: PLOS
Citação: Chaouiya C, Ourrad O, Lima R (2013) Majority Rules with Random Tie-Breaking in Boolean Gene Regulatory Networks. PLoS ONE 8(7): e69626. doi:10.1371/journal.pone.0069626
Resumo: We consider threshold boolean gene regulatory networks, where the update function of each gene is described as a majority rule evaluated among the regulators of that gene: it is turned ON when the sum of its regulator contributions is positive (activators contribute positively whereas repressors contribute negatively) and turned OFF when this sum is negative. In case of a tie (when contributions cancel each other out), it is often assumed that the gene keeps it current state. This framework has been successfully used to model cell cycle control in yeast. Moreover, several studies consider stochastic extensions to assess the robustness of such a model. Here, we introduce a novel, natural stochastic extension of the majority rule. It consists in randomly choosing the next value of a gene only in case of a tie. Hence, the resulting model includes deterministic and probabilistic updates. We present variants of the majority rule, including alternate treatments of the tie situation. Impact of these variants on the corresponding dynamical behaviours is discussed. After a thorough study of a class of two-node networks, we illustrate the interest of our stochastic extension using a published cell cycle model. In particular, we demonstrate that steady state analysis can be rigorously performed and can lead to effective predictions; these relate for example to the identification of interactions whose addition would ensure that a specific state is absorbing.
Peer review: yes
URI: http://hdl.handle.net/10400.7/439
DOI: 10.1371/journal.pone.0069626
Versão do Editor: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0069626
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