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dc.contributor.authorChelo, Ivo M.-
dc.contributor.authorNédli, Judit-
dc.contributor.authorGordo, Isabel-
dc.contributor.authorTeotónio, Henrique-
dc.date.accessioned2015-10-26T12:26:58Z-
dc.date.available2015-10-26T12:26:58Z-
dc.date.issued2013-09-13-
dc.identifier10.1038/ncomms3417-
dc.identifier.citationChelo, I. M. et al. An experimental test on the probability of extinction of new genetic variants. Nat. Commun. 4:2417 doi: 10.1038/ncomms3417 (2013).pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.7/440-
dc.description.abstractIn 1927, J.B.S. Haldane reasoned that the probability of fixation of new beneficial alleles is twice their fitness effect. This result, later generalized by M. Kimura, has since become the cornerstone of modern population genetics. There is no experimental test of Haldane's insight that new beneficial alleles are lost with high probability. Here we demonstrate that extinction rates decrease with increasing initial numbers of beneficial alleles, as expected, by performing invasion experiments with inbred lines of the nematode Caenorhabditis elegans. We further show that the extinction rates of deleterious alleles are higher than those of beneficial alleles, also as expected. Interestingly, we also find that for these inbred lines, when at intermediate frequencies, the fate of invaders might not result in their ultimate fixation or loss but on their maintenance. Our study confirms the key results from classical population genetics and highlights that the nature of adaptation can be complex.pt_PT
dc.description.sponsorshipHuman Frontiers Science Program grant: (RGP0045/2010).pt_PT
dc.language.isoengpt_PT
dc.publisherNature Publishing Grouppt_PT
dc.relationinfo:eu-repo/grantAgreement/EC/FP7/243285/EUpt_PT
dc.rightsopenAccesspt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectExtinction, Biologicalpt_PT
dc.subjectGenetic Variationpt_PT
dc.subjectProbabilitypt_PT
dc.titleAn experimental test on the probability of extinction of new genetic variantspt_PT
dc.typearticlept_PT
degois.publication.firstPage1pt_PT
degois.publication.lastPage8pt_PT
degois.publication.titleNature Communicationspt_PT
dc.relation.publisherversionhttp://www.nature.com/ncomms/2013/130913/ncomms3417/full/ncomms3417.htmlpt_PT
dc.peerreviewedyespt_PT
degois.publication.volume4pt_PT
dc.identifier.doi10.1038/ncomms3417-
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