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|Título:||Canalization and control in automata networks: body segmentation in Drosophila melanogaster|
Rocha, Luís M.
|Citação:||Marques-Pita M, Rocha LM (2013) Canalization and Control in Automata Networks: Body Segmentation in Drosophila melanogaster . PLoS ONE 8(3): e55946. doi:10.1371/journal.pone.0055946|
|Resumo:||We present schema redescription as a methodology to characterize canalization in automata networks used to model biochemical regulation and signalling. In our formulation, canalization becomes synonymous with redundancy present in the logic of automata. This results in straightforward measures to quantify canalization in an automaton (micro-level), which is in turn integrated into a highly scalable framework to characterize the collective dynamics of large-scale automata networks (macro-level). This way, our approach provides a method to link micro- to macro-level dynamics -- a crux of complexity. Several new results ensue from this methodology: uncovering of dynamical modularity (modules in the dynamics rather than in the structure of networks), identification of minimal conditions and critical nodes to control the convergence to attractors, simulation of dynamical behaviour from incomplete information about initial conditions, and measures of macro-level canalization and robustness to perturbations. We exemplify our methodology with a well-known model of the intra- and inter cellular genetic regulation of body segmentation in Drosophila melanogaster. We use this model to show that our analysis does not contradict any previous findings. But we also obtain new knowledge about its behaviour: a better understanding of the size of its wild-type attractor basin (larger than previously thought), the identification of novel minimal conditions and critical nodes that control wild-type behaviour, and the resilience of these to stochastic interventions. Our methodology is applicable to any complex network that can be modelled using automata, but we focus on biochemical regulation and signalling, towards a better understanding of the (decentralized) control that orchestrates cellular activity -- with the ultimate goal of explaining how do cells and tissues 'compute'.|
|Versão do Editor:||http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0055946|
|Aparece nas colecções:||CASCB- Artigos|
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|journal.pone.0055946.pdf||artigo principal||4,19 MB||Adobe PDF||Ver/Abrir|
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