Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.7/491
Título: Nutritional control of body size through FoxO-Ultraspiracle mediated ecdysone biosynthesis
Autor: Koyama, Takashi
Rodrigues, Marisa A
Athanasiadis, Alekos
Shingleton, Alexander W
Mirth, Christen K
Palavras-chave: D. melanogaster
body size
critical weight
developmental biology
insulin/insulin-like growth factor
nutrition-dependent signaling
stem cells
target of rapamycin
Data: 25-Nov-2014
Editora: Elife Sciences Publications
Resumo: Despite their fundamental importance for body size regulation, the mechanisms that stop growth are poorly understood. In Drosophila melanogaster, growth ceases in response to a peak of the molting hormone ecdysone that coincides with a nutrition-dependent checkpoint, critical weight. Previous studies indicate that insulin/insulin-like growth factor signaling (IIS)/Target of Rapamycin (TOR) signaling in the prothoracic glands (PGs) regulates ecdysone biosynthesis and critical weight. Here we elucidate a mechanism through which this occurs. We show that Forkhead Box class O (FoxO), a negative regulator of IIS/TOR, directly interacts with Ultraspiracle (Usp), part of the ecdysone receptor. While overexpressing FoxO in the PGs delays ecdysone biosynthesis and critical weight, disrupting FoxO-Usp binding reduces these delays. Further, feeding ecdysone to larvae eliminates the effects of critical weight. Thus, nutrition controls ecdysone biosynthesis partially via FoxO-Usp prior to critical weight, ensuring that growth only stops once larvae have achieved a target nutritional status.
Peer review: yes
URI: http://hdl.handle.net/10400.7/491
DOI: 10.7554/eLife.03091
Versão do Editor: http://elifesciences.org/content/3/e03091/article-info
Aparece nas colecções:PNAI - Artigos
DEE- Artigos

Ficheiros deste registo:
Ficheiro Descrição TamanhoFormato 
Mirth_Elife(2014).full.pdfmain article2,72 MBAdobe PDFVer/Abrir

FacebookTwitterDeliciousLinkedInDiggGoogle BookmarksMySpace
Formato BibTex MendeleyEndnote 

Todos os registos no repositório estão protegidos por leis de copyright, com todos os direitos reservados.