Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.7/496
Título: Rootletin organizes the ciliary rootlet to achieve neuron sensory function in Drosophila
Autor: Chen, Jieyan V
Kao, Ling-Rong
Jana, Swadhin C
Sivan-Loukianova, Elena
Mendonça, Susana
Cabrera, Oscar A
Singh, Priyanka
Cabernard, Clemens
Eberl, Daniel F
Bettencourt-Dias, Monica
Megraw, Timothy L
Palavras-chave: Drosophila melanogaster
Ciliary Rootlet
Neuron Sensory
Data: 26-Out-2015
Editora: The Rockefeller University Press
Citação: Rootletin organizes the ciliary rootlet to achieve neuron sensory function in Drosophila Jieyan V. Chen, Ling-Rong Kao, Swadhin C. Jana, Elena Sivan-Loukianova, Susana Mendonça, Oscar A. Cabrera, Priyanka Singh, Clemens Cabernard, Daniel F. Eberl, Monica Bettencourt-Dias, and Timothy L. Megraw J Cell Biol 2015 211:435-453. Published October 19, 2015, doi:10.1083/jcb.201502032
Resumo: Cilia are essential for cell signaling and sensory perception. In many cell types, a cytoskeletal structure called the ciliary rootlet links the cilium to the cell body. Previous studies indicated that rootlets support the long-term stability of some cilia. Here we report that Drosophila melanogaster Rootletin (Root), the sole orthologue of the mammalian paralogs Rootletin and C-Nap1, assembles into rootlets of diverse lengths among sensory neuron subtypes. Root mutant neurons lack rootlets and have dramatically impaired sensory function, resulting in behavior defects associated with mechanosensation and chemosensation. Root is required for cohesion of basal bodies, but the cilium structure appears normal in Root mutant neurons. We show, however, that normal rootlet assembly requires centrioles. The N terminus of Root contains a conserved domain and is essential for Root function in vivo. Ectopically expressed Root resides at the base of mother centrioles in spermatocytes and localizes asymmetrically to mother centrosomes in neuroblasts, both requiring Bld10, a basal body protein with varied functions.
Peer review: yes
URI: http://hdl.handle.net/10400.7/496
DOI: 10.1083/jcb.201502032
Versão do Editor: http://jcb.rupress.org/content/211/2/435.long
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