Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.7/499
Título: Dilp8 requires the neuronal relaxin receptor Lgr3 to couple growth to developmental timing
Autor: Garelli, Andres
Heredia, Fabiana
Casimiro, Andreia P.
Macedo, Andre
Nunes, Catarina
Garcez, Marcia
Dias, Angela R. Mantas
Volonte, Yanel A.
Uhlmann, Thomas
Caparros, Esther
Koyama, Takashi
Gontijo, Alisson M.
Palavras-chave: Biological sciences
Cell biology
Data: 29-Out-2015
Editora: Nature Publishing Group
Citação: Garelli, A. et al. Dilp8 requires the neuronal relaxin receptor Lgr3 to couple growth to developmental timing. Nat. Commun. 6:8732 doi: 10.1038/ ncomms9732 (2015).
Resumo: How different organs in the body sense growth perturbations in distant tissues to coordinate their size during development is poorly understood. Here we mutate an invertebrate orphan relaxin receptor gene, the Drosophila Leucine-rich repeat-containing G protein-coupled receptor 3 (Lgr3), and find body asymmetries similar to those found in insulin-like peptide 8 (dilp8) mutants, which fail to coordinate growth with developmental timing. Indeed, mutation or RNA intereference (RNAi) against Lgr3 suppresses the delay in pupariation induced by imaginal disc growth perturbation or ectopic Dilp8 expression. By tagging endogenous Lgr3 and performing cell type-specific RNAi, we map this Lgr3 activity to a new subset of CNS neurons, four of which are a pair of bilateral pars intercerebralis Lgr3-positive (PIL) neurons that respond specifically to ectopic Dilp8 by increasing cAMP-dependent signalling. Our work sheds new light on the function and evolution of relaxin receptors and reveals a novel neuroendocrine circuit responsive to growth aberrations.
Peer review: yes
URI: http://hdl.handle.net/10400.7/499
DOI: 10.1038/ncomms9732
Versão do Editor: http://www.nature.com/ncomms/2015/151029/ncomms9732/full/ncomms9732.html
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