Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.7/528
Título: Evidence of IL-17, IP-10, and IL-10 involvement in multiple-organ dysfunction and IL-17 pathway in acute renal failure associated to Plasmodium falciparum malaria
Autor: Herbert, Fabien
Tchitchek, Nicolas
Bansal, Devendra
Jacques, Julien
Pathak, Sulabha
Bécavin, Christophe
Fesel, Constantin
Dalko, Esther
Cazenave, Pierre-André
Preda, Cristian
Ravindran, Balachandran
Sharma, Shobhona
Das, Bidyut
Pied, Sylviane
Palavras-chave: Plasmodium falciparum
Severe malaria
Cerebral malaria
Acute-renal failure
Malaria associated organ failure
IL-17
Cytokines
Biomarkers
Data: 24-Nov-2015
Editora: BioMed Central
Resumo: Plasmodium falciparum malaria in India is characterized by high rates of severe disease, with multiple organ dysfunction (MOD)-mainly associated with acute renal failure (ARF)-and increased mortality. The objective of this study is to identify cytokine signatures differentiating severe malaria patients with MOD, cerebral malaria (CM), and cerebral malaria with MOD (CM-MOD) in India. We have previously shown that two cytokines clusters differentiated CM from mild malaria in Maharashtra. Hence, we also aimed to determine if these cytokines could discriminate malaria subphenotypes in Odisha.
Peer review: yes
URI: http://hdl.handle.net/10400.7/528
DOI: 10.1186/s12967-015-0731-6
Versão do Editor: http://www.translational-medicine.com/content/13/1/369
Aparece nas colecções:LAIR articles

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