Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.7/529
Título: Adaptive immunity increases the pace and predictability of evolutionary change in commensal gut bacteria
Autor: Barroso-Batista, João
Demengeot, Jocelyne
Gordo, Isabel
Palavras-chave: Biological sciences
Evolution
Genetics
Microbiology
Data: 30-Nov-2015
Editora: Nature Publishing Group
Citação: Barroso-Batista, J. et al. Adaptive immunity increases the pace and predictability of evolutionary change in commensal gut bacteria. Nat. Commun. 6:8945 doi: 10.1038/ncomms9945 (2015).
Resumo: Co-evolution between the mammalian immune system and the gut microbiota is believed to have shaped the microbiota's astonishing diversity. Here we test the corollary hypothesis that the adaptive immune system, directly or indirectly, influences the evolution of commensal species. We compare the evolution of Escherichia coli upon colonization of the gut of wild-type and Rag2(-/-) mice, which lack lymphocytes. We show that bacterial adaptation is slower in immune-compromised animals, a phenomenon explained by differences in the action of natural selection within each host. Emerging mutations exhibit strong beneficial effects in healthy hosts but substantial antagonistic pleiotropy in immune-deficient mice. This feature is due to changes in the composition of the gut microbiota, which differs according to the immune status of the host. Our results indicate that the adaptive immune system influences the tempo and predictability of E. coli adaptation to the mouse gut.
Peer review: yes
URI: http://hdl.handle.net/10400.7/529
DOI: 10.1038/ncomms9945
Versão do Editor: http://www.nature.com/ncomms/2015/151130/ncomms9945/full/ncomms9945.html
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