Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.7/536
Título: Decrease of CD68 Synovial Macrophages in Celastrol Treated Arthritic Rats
Autor: Cascão, Rita
Vidal, Bruno
Lopes, Inês P.
Paisana, Eunice
Rino, José
Moita, Luis F.
Fonseca, João E.
Palavras-chave: Arthritis
Macrophages
Inflammation
Inflammatory diseases
Cytokines
Rheumatoid arthritis
Ankles
Hematoxylin staining
Data: 11-Dez-2015
Editora: PLOS
Citação: Cascão R, Vidal B, Lopes IP, Paisana E, Rino J, Moita LF, et al. (2015) Decrease of CD68 Synovial Macrophages in Celastrol Treated Arthritic Rats. PLoS ONE 10(12): e0142448. doi:10.1371/journal.pone.0142448
Resumo: Rheumatoid arthritis (RA) is a chronic immune-mediated inflammatory disease characterized by cellular infiltration into the joints, hyperproliferation of synovial cells and bone damage. Available treatments for RA only induce remission in around 30% of the patients, have important adverse effects and its use is limited by their high cost. Therefore, compounds that can control arthritis, with an acceptable safety profile and low production costs are still an unmet need. We have shown, in vitro, that celastrol inhibits both IL-1β and TNF, which play an important role in RA, and, in vivo, that celastrol has significant anti-inflammatory properties. Our main goal in this work was to test the effect of celastrol in the number of sublining CD68 macrophages (a biomarker of therapeutic response for novel RA treatments) and on the overall synovial tissue cellularity and joint structure in the adjuvant-induced rat model of arthritis (AIA).
Peer review: yes
URI: http://hdl.handle.net/10400.7/536
DOI: 10.1371/journal.pone.0142448
Versão do Editor: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0142448
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