Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.7/537
Título: Studies in the mouse model identify strain variability as a major determinant of disease outcome in Leishmania infantum infection
Autor: Marques, Filipe
Vale-Costa, Sílvia
Cruz, Tânia
Marques, Joana Moreira
Silva, Tânia
Neves, João Vilares
Cortes, Sofia
Fernandes, Ana
Rocha, Eduardo
Appelberg, Rui
Rodrigues, Pedro
Tomás, Ana M.
Gomes, Maria Salomé
Palavras-chave: Leishmania infantum
Data: Dez-2015
Editora: BioMed Central
Resumo: Visceral leishmaniasis is a severe and potentially fatal disease caused by protozoa of the genus Leishmania, transmitted by phlebotomine sandflies. In Europe and the Mediterranean region, L. infantum is the commonest agent of visceral leishmaniasis, causing a wide spectrum of clinical manifestations, including asymptomatic carriage, cutaneous lesions and severe visceral disease. Visceral leishmaniasis is more frequent in immunocompromised individuals and data obtained in experimental models of infection have highlighted the importance of the host immune response, namely the efficient activation of host's macrophages, in determining infection outcome. Conversely, few studies have addressed a possible contribution of parasite variability to this outcome.
Peer review: yes
URI: http://hdl.handle.net/10400.7/537
DOI: 10.1186/s13071-015-1259-6
Versão do Editor: http://www.parasitesandvectors.com/content/8/1/644#refs
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