Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.7/538
Título: Multiple Resistance at No Cost: Rifampicin and Streptomycin a Dangerous Liaison in the Spread of Antibiotic Resistance
Autor: Durão, Paulo
Trindade, Sandra
Sousa, Ana
Gordo, Isabel
Palavras-chave: epistasis
Data: Out-2015
Editora: Oxford University Press
Citação: Paulo Durão, Sandra Trindade, Ana Sousa, and Isabel Gordo Multiple Resistance at No Cost: Rifampicin and Streptomycin a Dangerous Liaison in the Spread of Antibiotic Resistance Mol Biol Evol (2015) 32 (10): 2675-2680 first published online June 30, 2015 doi:10.1093/molbev/msv143
Resumo: Evidence is mounting that epistasis is widespread among mutations. The cost of carrying two deleterious mutations, or the advantage of acquiring two beneficial alleles, is typically lower that the sum of their individual effects. Much less is known on epistasis between beneficial and deleterious mutations, even though this is key to the amount of genetic hitchhiking that may occur during evolution. This is particularly important in the context of antibiotic resistance: Most resistances are deleterious, but some can be beneficial and remarkably rifampicin resistance can emerge de novo in populations evolving without antibiotics. Here we show pervasive positive pairwise epistasis on Escherichia coli fitness between beneficial mutations, which confer resistance to rifampicin, and deleterious mutations, which confer resistance to streptomycin. We find that 65% of double resistant strains outcompete sensitive bacteria in an environment devoid of antibiotics. Weak beneficial mutations may therefore overcome strong deleterious mutations and can even render double mutants strong competitors.
Peer review: yes
URI: http://hdl.handle.net/10400.7/538
DOI: 10.1093/molbev/msv143
Versão do Editor: http://mbe.oxfordjournals.org/content/32/10/2675.long
Aparece nas colecções:EB - Articles

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