Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.7/540
Título: Evolution of clonal populations approaching a fitness peak
Autor: Gordo, I.
Campos, P. R. A.
Palavras-chave: experimental evolution
clonal interference
molecular clock
epistasis
fitness peak
Data: 23-Fev-2012
Editora: The Royal Society
Citação: Gordo I, Campos PRA. 2012 Evolution of clonal populations approaching a fitness peak. Biol Lett 9: 20120239. http://dx.doi.org/10.1098/rsbl.2012.0239
Resumo: Populations facing novel environments are expected to evolve through the accumulation of adaptive substitutions. The dynamics of adaptation depend on the fitness landscape and possibly on the genetic background on which new mutations arise. Here, we model the dynamics of adaptive evolution at the phenotypic and genotypic levels, focusing on a Fisherian landscape characterized by a single peak. We find that Fisher's geometrical model of adaptation, extended to allow for small random environmental variations, is able to explain several features made recently in experimentally evolved populations. Consistent with data on populations evolving under controlled conditions, the model predicts that mean population fitness increases rapidly when populations face novel environments and then achieves a dynamic plateau, the rate of molecular evolution is remarkably constant over long periods of evolution, mutators are expected to invade and patterns of epistasis vary along the adaptive walk. Negative epistasis is expected in the initial steps of adaptation but not at later steps, a prediction that remains to be tested. Furthermore, populations are expected to exhibit high levels of phenotypic diversity at all times during their evolution. This implies that populations are possibly able to adapt rapidly to novel abiotic environments.
Peer review: yes
URI: http://hdl.handle.net/10400.7/540
DOI: 10.1098/rsbl.2012.0239
Versão do Editor: http://rsbl.royalsocietypublishing.org/content/9/1/20120239.long
Aparece nas colecções:EB - Artigos

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GordoandCamposBiologyLetters29Jan2012-Paulo.pdfartigo principal227,36 kBAdobe PDFVer/Abrir
GordoandCamposSupplemental_Information.pdfmaterial suplementar385,09 kBAdobe PDFVer/Abrir


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