Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.7/544
Título: The evolution of X chromosome inactivation in mammals: the demise of Ohno’s hypothesis?
Autor: Pessia, Eugénie
Engelstädter, Jan
Marais, Gabriel A. B.
Palavras-chave: Sex chromosomes
Sex determination
Dosage compensation
Dosage-sensitive genes
Parental antagonism model
RNAseq data
Data: Abr-2014
Editora: Springer
Resumo: Ohno's hypothesis states that dosage compensation in mammals evolved in two steps: a twofold hyperactivation of the X chromosome in both sexes to compensate for gene losses on the Y chromosome, and silencing of one X (X-chromosome inactivation, XCI) in females to restore optimal dosage. Recent tests of this hypothesis have returned contradictory results. In this review, we explain this ongoing controversy and argue that a novel view on dosage compensation evolution in mammals is starting to emerge. Ohno's hypothesis may be true for a few, dosage-sensitive genes only. If so few genes are compensated, then why has XCI evolved as a chromosome-wide mechanism? This and several other questions raised by the new data in mammals are discussed, and future research directions are proposed.
Peer review: yes
URI: http://hdl.handle.net/10400.7/544
DOI: 10.1007/s00018-013-1499-6
Versão do Editor: http://link.springer.com/article/10.1007%2Fs00018-013-1499-6#
Aparece nas colecções:EB - Artigos

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