Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.7/55
Título: On the determinants of population structure in antigenically diverse pathogens
Autor: Gomes, M. G. M.
Medley, G. F.
Nokes, D. J.
Palavras-chave: infection
multiple strains
cross-immunity
population dynamics
pattern formation
transmission dynamics
evolution
Data: Fev-2002
Citação: Gomes, M.G.M., Medley, G.F., Nokes, D.J.(2002)."On the determinants of population structure in antigenically diverse pathogens".Proceedings. Biological sciences, R.S.269(1488):227-33
Resumo: Many pathogens exhibit antigenic diversity and elicit strain-specific immune responses. This potential for cross-immunity structure in the host resource motivates the development of mathematical models, stressing competition for susceptible hosts in driving pathogen population dynamics and genetics. Here we establish that certain model formulations exhibit characteristics of prototype pattern-forming systems, with pathogen population structure emerging as three possible patterns: (i) incidence is steady and homogeneous; (ii) incidence is steady but heterogeneous; and (iii) incidence shows oscillatory dynamics, with travelling waves in strain-space. Results are robust to strain number, but sensitive to the mechanism of cumulative immunity
URI: http://hdl.handle.net/10400.7/55
ISSN: 0962-8452
Versão do Editor: http://dx.doi.org/10.1098/rspb.2001.1869
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