Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.7/637
Título: Regulatory T Cells Accumulate in the Lung Allergic Inflammation and Efficiently Suppress T-Cell Proliferation but Not Th2 Cytokine Production
Autor: Faustino, Lucas
Mucida, Daniel
Keller, Alexandre Castro
Demengeot, Jocelyne
Bortoluci, Karina
Sardinha, Luiz Roberto
Carla Takenaka, Maisa
Basso, Alexandre Salgado
Faria, Ana Maria Caetano
Russo, Momtchilo
Palavras-chave: Animals
Antigens, CD4
Asthma
Cytokines
Female
Interleukin-2 Receptor alpha Subunit
Lung
Mice
Mice, Inbred BALB C
Pneumonia
T-Lymphocytes, Regulatory
Th2 Cells
Cell Proliferation
Data: 2012
Editora: Hindawi Publishing Corporation
Citação: Lucas Faustino, Daniel Mucida, Alexandre Castro Keller, et al., “Regulatory T Cells Accumulate in the Lung Allergic Inflammation and Efficiently Suppress T-Cell Proliferation but Not Th2 Cytokine Production,” Clinical and Developmental Immunology, vol. 2012, Article ID 721817, 13 pages, 2012. doi:10.1155/2012/721817
Resumo: Foxp3(+)CD25(+)CD4(+) regulatory T cells are vital for peripheral tolerance and control of tissue inflammation. In this study, we characterized the phenotype and monitored the migration and activity of regulatory T cells present in the airways of allergic or tolerant mice after allergen challenge. To induce lung allergic inflammation, mice were sensitized twice with ovalbumin/aluminum hydroxide gel and challenged twice with intranasal ovalbumin. Tolerance was induced by oral administration of ovalbumin for 5 consecutive days prior to OVA sensitization and challenge. We detected regulatory T cells (Foxp3(+)CD25(+)CD4(+) T cells) in the airways of allergic and tolerant mice; however, the number of regulatory T cells was more than 40-fold higher in allergic mice than in tolerant mice. Lung regulatory T cells expressed an effector/memory phenotype (CCR4(high)CD62L(low)CD44(high)CD54(high)CD69(+)) that distinguished them from naive regulatory T cells (CCR4(int)CD62L(high)CD44(int)CD54(int)CD69(-)). These regulatory T cells efficiently suppressed pulmonary T-cell proliferation but not Th2 cytokine production.
Descrição: This deposit is composed by a publication in which the IGC' authors have had the role of collaboration (it's a collaboration publication). This type of deposit in ARCA is in restrictedAccess (it can't be in open access to the public), and could only be accessed by two ways: either by requesting a legal copy to the author (the email contact present in this deposit) or by visiting the following link: http://bdpi.usp.br/single.php?_id=002294086
Peer review: yes
URI: http://hdl.handle.net/10400.7/637
DOI: 10.1155/2012/721817
Versão do Editor: http://www.hindawi.com/journals/jir/2012/721817/
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