Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.7/750
Título: Centrioles: active players or passengers during mitosis?
Autor: Debec, Alain
Sullivan, William
Bettencourt-Dias, Monica
Palavras-chave: Animals
Cell Division
Cell Line
Spindle Apparatus
Data: 19-Mar-2010
Editora: Springer Verlag
Citação: Debec, A., Sullivan, W. & Bettencourt-Dias, M. Cell. Mol. Life Sci. (2010) 67: 2173. doi:10.1007/s00018-010-0323-9
Resumo: Centrioles are cylinders made of nine microtubule (MT) triplets present in many eukaryotes. Early studies, where centrosomes were seen at the poles of the mitotic spindle led to their coining as "the organ for cell division". However, a variety of subsequent observational and functional studies showed that centrosomes might not always be essential for mitosis. Here we review the arguments in this debate. We describe the centriole structure and its distribution in the eukaryotic tree of life and clarify its role in the organization of the centrosome and cilia, with an historical perspective. An important aspect of the debate addressed in this review is how centrioles are inherited and the role of the spindle in this process. In particular, germline inheritance of centrosomes, such as their de novo formation in parthenogenetic species, poses many interesting questions. We finish by discussing the most likely functions of centrioles and laying out new research avenues.
Descrição: There is no public supplementary material available.
Peer review: yes
URI: http://hdl.handle.net/10400.7/750
DOI: 10.1007/s00018-010-0323-9
Versão do Editor: http://link.springer.com/article/10.1007%2Fs00018-010-0323-9
Aparece nas colecções:CCR - Artigos

Ficheiros deste registo:
Ficheiro Descrição TamanhoFormato 
Cell.Mol.Life.Sci_(2010)_67-2173_2194.pdfmain article862,88 kBAdobe PDFVer/Abrir

FacebookTwitterDeliciousLinkedInDiggGoogle BookmarksMySpace
Formato BibTex MendeleyEndnote 

Todos os registos no repositório estão protegidos por leis de copyright, com todos os direitos reservados.