Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.7/780
Título: Glutamate receptor-like channels are essential for chemotaxis and reproduction in mosses
Autor: Ortiz-Ramírez, Carlos
Michard, Erwan
Simon, Alexander A.
Damineli, Daniel S. C.
Hernández-Coronado, Marcela
Becker, Jörg D.
Feijó, José A.
Palavras-chave: Fertilization
Evolutionary developmental biology
Data: 24-Jul-2017
Editora: Nature Publishing Group
Citação: Ortiz-Ramírez, C. et al. Glutamate receptor-like channels are essential for chemotaxis and reproduction in mosses. Nature http://dx.doi.org/10.1038/nature23478 (2017)
Resumo: Glutamate receptors are well characterized channels that mediate cell-to-cell communication during neurotransmission in animals. Nevertheless, information regarding their functional role in organisms without nervous systems is still limited. In plants, Glutamate Receptor-like (GLR) genes have been implicated in defence against pathogens, reproduction, control of stomata aperture and light signal transduction(1-5). However, the numerous GLR genes present in angiosperm genomes (20 to 70)(6) has prevented the observation of strong phenotypes in loss-of-function mutants. Here, we show that in the moss Physcomitrella patens, a basal land plant, mutation of GLR genes cause sperm failure in targeting the female reproductive organs. In addition, we show that GLR genes encode non-selective Ca(2+) permeable channels that can regulate cytoplasmic Ca(2+) and are needed to induce the expression of a BELL1-like transcription factor essential for zygote development. Our work reveals novel functions for GLRs in sperm chemotaxis and transcriptional regulation. Sperm chemotaxis is essential for fertilization in both animals and early land plants like bryophytes and pteridophytes. Therefore, our results are suggestive that ionotropic glutamate receptors may have been conserved throughout plant evolution to mediate cell-to-cell communication during sexual reproduction.
Descrição: The deposited article version is a "Accelerated Article Preview" provided by Nature Publishing Group, and it contains attached the supplementary materials within the pdf.». This publication hasn't any creative commons license associated.
Peer review: yes
URI: http://hdl.handle.net/10400.7/780
DOI: 10.1038/nature23478
Versão do Editor: https://www.nature.com/nature/journal/vaap/ncurrent/full/nature23478.html
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