Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.7/783
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dc.contributor.authorLopez, Saioa-
dc.contributor.authorThomas, Mark G-
dc.contributor.authorvan Dorp, Lucy-
dc.contributor.authorAnsari-Pour, Naser-
dc.contributor.authorStewart, Sarah-
dc.contributor.authorJones, Abigail L-
dc.contributor.authorJelinek, Erik-
dc.contributor.authorChikhi, Lounes-
dc.contributor.authorParfitt, Tudor-
dc.contributor.authorBradman, Neil-
dc.contributor.authorWeale, Michael E-
dc.contributor.authorHellenthal, Garrett-
dc.date.accessioned2017-09-04T14:34:43Z-
dc.date.available2017-09-04T14:34:43Z-
dc.date.issued2017-08-
dc.identifier.citationSaioa López, Mark G. Thomas, Lucy van Dorp, Naser Ansari-Pour, Sarah Stewart, Abigail L. Jones, Erik Jelinek, Lounès Chikhi, Tudor Parfitt, Neil Bradman, Michael E. Weale, Garrett Hellenthal, The Genetic Legacy of Zoroastrianism in Iran and India: Insights into Population Structure, Gene Flow, and Selection, The American Journal of Human Genetics, Available online 24 August 2017, ISSN 0002-9297, https://doi.org/10.1016/j.ajhg.2017.07.013. (http://www.sciencedirect.com/science/article/pii/S0002929717302914)pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.7/783-
dc.descriptionThe deposited article version is a "Pre-print version" provided by Biorxiv posted online on April 18, 2017 - 12:26, and it contains attached the supplementary materials within the pdf.pt_PT
dc.description.abstractZoroastrianism is one of the oldest extant religions in the world, originating in Persia (present-day Iran) during the second millennium BCE. Historical records indicate that migrants from Persia brought Zoroastrianism to India, but there is debate over the timing of these migrations. Here we present genome-wide autosomal, Y chromosome, and mitochondrial DNA data from Iranian and Indian Zoroastrians and neighboring modern-day Indian and Iranian populations and conduct a comprehensive genome-wide genetic analysis in these groups. Using powerful haplotype-based techniques, we find that Zoroastrians in Iran and India have increased genetic homogeneity relative to other sampled groups in their respective countries, consistent with their current practices of endogamy. Despite this, we infer that Indian Zoroastrians (Parsis) intermixed with local groups sometime after their arrival in India, dating this mixture to 690–1390 CE and providing strong evidence that Iranian Zoroastrian ancestry was maintained primarily through the male line. By making use of the rich information in DNA from ancient human remains, we also highlight admixture in the ancestors of Iranian Zoroastrians dated to 570 BCE–746 CE, older than admixture seen in any other sampled Iranian group, consistent with a long-standing isolation of Zoroastrians from outside groups. Finally, we report results, and challenges, from a genome-wide scan to identify genomic regions showing signatures of positive selection in present-day Zoroastrians that might correlate to the prevalence of particular diseases among these communities.pt_PT
dc.description.sponsorshipBBSRC grant: (BB/L009382/1); Wellcome Trust and the Royal Society Sir Henry Dale Fellowship: (098386/Z/12/Z); National Institute for Health Research University College London Hospitals Biomedical Research Centre; Wellcome Trust Senior Investigator Award grant: (100719/Z/12/Z); EPSRC grant: (EP/F500351/1).pt_PT
dc.language.isoengpt_PT
dc.publisherElsevierpt_PT
dc.relationBB/L009382/1pt_PT
dc.relation098386/Z/12/Zpt_PT
dc.relation100719/Z/12/Zpt_PT
dc.relationEP/F500351/1pt_PT
dc.rightsopenAccesspt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectpopulation geneticspt_PT
dc.subjectgenetic structurept_PT
dc.subjectadmixturept_PT
dc.subjectZoroastrianismpt_PT
dc.subjectrecent isolationpt_PT
dc.subjectIranpt_PT
dc.subjectIndiapt_PT
dc.subjectParsispt_PT
dc.titleThe genetic legacy of Zoroastrianism in Iran and India: Insights into population structure, gene flow and selection.pt_PT
dc.typearticlept_PT
dc.description.versioninfo:eu-repo/semantics/acceptedVersionpt_PT
degois.publication.firstPage1pt_PT
degois.publication.lastPage52pt_PT
degois.publication.titleAmerican Journal of Human Geneticspt_PT
dc.relation.publisherversionhttp://www.sciencedirect.com/science/article/pii/S0002929717302914pt_PT
dc.peerreviewednopt_PT
dc.identifier.doi10.1101/128272pt_PT
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