Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.7/797
Título: Genetics of host-parasite interactions: towards a comprehensive dissection of Drosophila resistance to viral infection
Autor: Magalhães, Sara
Sucena, Élio
Palavras-chave: adaptation
genomics/proteomics
host-parasite interactions
insects
quantitative genetics
Data: 7-Out-2016
Editora: Wiley
Citação: Magalhães, S. and Sucena, É. (2016), Genetics of host–parasite interactions: towards a comprehensive dissection of Drosophila resistance to viral infection. Mol Ecol, 25: 4981–4983. doi:10.1111/mec.13834
Resumo: One of the major challenges in evolutionary biology is to unravel the genetic basis of adaptation. This issue has been gaining momentum in recent years with the accelerated development of novel genetic and genomic techniques and resources. In this issue of Molecular Ecology, Cogni et al. (2016) address the genetic basis of resistance to two viruses in Drosophila melanogaster using a panel of recombinant inbred lines with unprecedented resolution allowing detection of rare alleles and/or alleles of small effect. The study confirms the role of previously identified genes of major effect and adds novel regions with minor effect to the genetic basis of Drosophila resistance to the Drosophila C virus or the sigma virus. Additional analyses reveal the absence of cross-resistance and of epistasis between the various genomic regions. This detailed information on the genetic architecture of host resistance constitutes an important step towards the understanding of both the physiology of antiviral immunity and the evolution of host-parasite interactions.
Descrição: The deposited article is a post-print version and has peer-review. There are no funders and sponsors indicated explicitly in the document. There is no public supplementary material available. This publication hasn't any creative commons license associated.
Peer review: yes
URI: http://hdl.handle.net/10400.7/797
DOI: 10.1111/mec.13834
Versão do Editor: http://onlinelibrary.wiley.com/doi/10.1111/mec.13834/abstract
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