Please use this identifier to cite or link to this item: http://hdl.handle.net/10400.7/814
Title: Changes in Expression of the CLOCK Gene in Obstructive Sleep Apnea Syndrome Patients Are Not Reverted by Continuous Positive Airway Pressure Treatment
Author: Moreira, Susana
Rodrigues, Raquel
Barros, André B.
Pejanovic, Nadja
Neves-Costa, Ana
Pedroso, Dora
Pereira, Cláudia
Fernandes, Dina
Rodrigues, João Valença
Barbara, Cristina
Moita, Luís Ferreira
Keywords: obstructive sleep apnea syndrome
clock genes
continuous positive airway pressure
slow wave sleep
Metabolic Syndrome
Circadian Rhythms
Issue Date: 6-Nov-2017
Publisher: Frontiers Media
Citation: Moreira S, Rodrigues R, Barros AB, Pejanovic N, Neves-Costa A, Pedroso D, Pereira C, Fernandes D, Rodrigues JV, Barbara C and Moita LF (2017) Changes in Expression of the CLOCK Gene in Obstructive Sleep Apnea Syndrome Patients Are Not Reverted by Continuous Positive Airway Pressure Treatment. Front. Med. 4:187. doi: 10.3389/fmed.2017.00187
Abstract: Metabolic syndrome and cardiovascular disease are strongly associated with obstructive sleep apnea syndrome (OSAS), which causes substantial changes to normal circadian physiological functions, including metabolic pathways. Because core clock genes are known to be modulated by sleep/vigilance cycles, we asked whether the expression level of mRNA coding for clock genes is altered in non-treated OSAS patients and if it can be corrected by standard continuous positive airway pressure (CPAP) treatment.
Description: This deposit is composed by the main article plus the supplementary materials of the publication.
Peer review: yes
URI: http://hdl.handle.net/10400.7/814
DOI: 10.3389/fmed.2017.00187
Publisher Version: https://www.frontiersin.org/articles/10.3389/fmed.2017.00187/full
Appears in Collections:III- Artigos

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