Please use this identifier to cite or link to this item: http://hdl.handle.net/10400.7/820
Title: Tolerogenic insulin peptide therapy precipitates type 1 diabetes
Author: Bergman, Marie-Louise
Lopes-Carvalho, Thiago
Martins, Ana-Catarina
Grieco, Fabio A.
Eizirik, Décio L.
Demengeot, Jocelyne
Keywords: Animals
Autoantibodies
Diabetes Mellitus, Type 1
Female
Hyperglycemia
Insulin
Insulin Antibodies
Mice, Inbred NOD
Microscopy, Fluorescence
Vaccination
Epitopes
Autoimmunity
Issue Date: 23-May-2017
Publisher: Rockefeller University Press
Citation: Tolerogenic insulin peptide therapy precipitates type 1 diabetes Marie-Louise Bergman, Thiago Lopes-Carvalho, Ana-Catarina Martins, Fabio A. Grieco, Décio L. Eizirik, Jocelyne Demengeot Journal of Experimental Medicine Jul 2017, 214 (7) 2153-2156; DOI: 10.1084/jem.20160471
Abstract: Daniel et al. (https://doi.org/10.1084/jem.20110574) have previously published in JEM a study on the preventive effect of tolerogenic vaccination with a strong agonist insulin mimetope in type 1 diabetes. Our study now challenges these results and shows that osmotic pump delivery of the modified insulin peptide R22E did not prevent hyperglycemia, accelerated disease onset, increased its incidence, and worsened insulitis.
Description: The deposited article version contains attached the supplementary materials within the pdf.
Peer review: yes
URI: http://hdl.handle.net/10400.7/820
DOI: 10.1084/jem.20160471
Publisher Version: http://jem.rupress.org/content/214/7/2153.long
Appears in Collections:LP - Artigos

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