Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.7/820
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dc.contributor.authorBergman, Marie-Louise-
dc.contributor.authorLopes-Carvalho, Thiago-
dc.contributor.authorMartins, Ana-Catarina-
dc.contributor.authorGrieco, Fabio A.-
dc.contributor.authorEizirik, Décio L.-
dc.contributor.authorDemengeot, Jocelyne-
dc.date.accessioned2017-12-11T14:54:38Z-
dc.date.available2017-12-11T14:54:38Z-
dc.date.issued2017-05-23-
dc.identifier.citationTolerogenic insulin peptide therapy precipitates type 1 diabetes Marie-Louise Bergman, Thiago Lopes-Carvalho, Ana-Catarina Martins, Fabio A. Grieco, Décio L. Eizirik, Jocelyne Demengeot Journal of Experimental Medicine Jul 2017, 214 (7) 2153-2156; DOI: 10.1084/jem.20160471pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.7/820-
dc.descriptionThe deposited article version contains attached the supplementary materials within the pdf.pt_PT
dc.description.abstractDaniel et al. (https://doi.org/10.1084/jem.20110574) have previously published in JEM a study on the preventive effect of tolerogenic vaccination with a strong agonist insulin mimetope in type 1 diabetes. Our study now challenges these results and shows that osmotic pump delivery of the modified insulin peptide R22E did not prevent hyperglycemia, accelerated disease onset, increased its incidence, and worsened insulitis.pt_PT
dc.description.sponsorshipEuropean Union’s (EU FP7) Large-Scale Focused Collaborative Research Project on Natural Immunomodulators as Novel Immunotherapies for Type 1 Diabetes grant: (NAIMIT, 241447).pt_PT
dc.language.isoporpt_PT
dc.publisherRockefeller University Presspt_PT
dc.relationinfo:eu-repo/grantAgreement/EC/FP7/241447/EUpt_PT
dc.rightsopenAccesspt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/pt_PT
dc.subjectAnimalspt_PT
dc.subjectAutoantibodiespt_PT
dc.subjectDiabetes Mellitus, Type 1pt_PT
dc.subjectFemalept_PT
dc.subjectHyperglycemiapt_PT
dc.subjectInsulinpt_PT
dc.subjectInsulin Antibodiespt_PT
dc.subjectMice, Inbred NODpt_PT
dc.subjectMicroscopy, Fluorescencept_PT
dc.subjectVaccinationpt_PT
dc.subjectEpitopespt_PT
dc.subjectAutoimmunitypt_PT
dc.titleTolerogenic insulin peptide therapy precipitates type 1 diabetespt_PT
dc.typearticlept_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
degois.publication.firstPage2153pt_PT
degois.publication.issue7pt_PT
degois.publication.lastPage2156pt_PT
degois.publication.titleJournal of Experimental Medicinept_PT
dc.relation.publisherversionhttp://jem.rupress.org/content/214/7/2153.longpt_PT
dc.peerreviewedyespt_PT
degois.publication.volume214pt_PT
dc.identifier.doi10.1084/jem.20160471pt_PT
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