Please use this identifier to cite or link to this item:
Title: A structural road map to unveil basal body composition and assembly
Author: Jana, Swadhin C
Machado, Pedro
Bettencourt-Dias, Mónica
Keywords: Animals
Basal Body
Issue Date: 1-Feb-2012
Publisher: EMBO Press
Citation: Swadhin C Jana, Pedro Machado, Mónica Bettencourt‐Dias (2012). A structural road map to unveil basal body composition and assembly. EMBO J. 31(3):519-21. DOI 10.1038/emboj.2011.474
Abstract: The Basal Body (BB) acts as the template for the axoneme, the microtubule‐basedstructure of cilia and flagella. Although several proteins were recently implicatedin both centriole and BB assembly and function, their molecular mechanisms are stillpoorly characterized. In this issue of The EMBO journal, Li and coworkersdescribe for the first time the near‐native structure of the BB at 33 Åresolution obtained by Cryo‐Electron Microscopy analysis of wild‐type (WT) isolatedChlamydomonas BBs. They identified several uncharacterized non‐tubulinstructures and variations along the length of the BB, which likely reflect thebinding and function of numerous macromolecular complexes. These complexes areexpected to define BB intrinsic properties, such as its characteristic structure andstability. Similarly to the high‐resolution structures of ribosome and nuclear porecomplexes, this study will undoubtedly contribute towards the future analysis ofcentriole and BB biogenesis, maintenance and function.
Description: The deposited article is a post-print version and has been submitted to peer review.
This publication hasn't any creative commons license associated.
There is no public supplementary material available.
Peer review: yes
DOI: 10.1038/emboj.2011.474
Publisher Version:
Appears in Collections:CCR - Artigos

Files in This Item:
File Description SizeFormat 
Jana_EMBOJ2012_PostPrint.pdfmain article893,83 kBAdobe PDFView/Open

FacebookTwitterDeliciousLinkedInDiggGoogle BookmarksMySpace
Formato BibTex MendeleyEndnote Degois 

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.