Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.7/834
Título: A structural road map to unveil basal body composition and assembly
Autor: Jana, Swadhin C
Machado, Pedro
Bettencourt-Dias, Mónica
Palavras-chave: Animals
Cilia
Microtubules
Basal Body
Data: 1-Fev-2012
Editora: EMBO Press
Citação: Swadhin C Jana, Pedro Machado, Mónica Bettencourt‐Dias (2012). A structural road map to unveil basal body composition and assembly. EMBO J. 31(3):519-21. DOI 10.1038/emboj.2011.474
Resumo: The Basal Body (BB) acts as the template for the axoneme, the microtubule‐basedstructure of cilia and flagella. Although several proteins were recently implicatedin both centriole and BB assembly and function, their molecular mechanisms are stillpoorly characterized. In this issue of The EMBO journal, Li and coworkersdescribe for the first time the near‐native structure of the BB at 33 Åresolution obtained by Cryo‐Electron Microscopy analysis of wild‐type (WT) isolatedChlamydomonas BBs. They identified several uncharacterized non‐tubulinstructures and variations along the length of the BB, which likely reflect thebinding and function of numerous macromolecular complexes. These complexes areexpected to define BB intrinsic properties, such as its characteristic structure andstability. Similarly to the high‐resolution structures of ribosome and nuclear porecomplexes, this study will undoubtedly contribute towards the future analysis ofcentriole and BB biogenesis, maintenance and function.
Descrição: The deposited article is a post-print version and has been submitted to peer review.
This publication hasn't any creative commons license associated.
There is no public supplementary material available.
Peer review: yes
URI: http://hdl.handle.net/10400.7/834
DOI: 10.1038/emboj.2011.474
Versão do Editor: http://emboj.embopress.org/content/31/3/519
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