Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.7/835
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dc.contributor.authorCarvalho-Santos, Zita-
dc.contributor.authorMachado, Pedro-
dc.contributor.authorAlvarez-Martins, Inês-
dc.contributor.authorGouveia, Susana M.-
dc.contributor.authorJana, Swadhin C.-
dc.contributor.authorDuarte, Paulo-
dc.contributor.authorAmado, Tiago-
dc.contributor.authorBranco, Pedro-
dc.contributor.authorFreitas, Micael C.-
dc.contributor.authorSilva, Sara T.N.-
dc.contributor.authorAntony, Claude-
dc.contributor.authorBandeiras, Tiago M.-
dc.contributor.authorBettencourt-Dias, Mónica-
dc.date.accessioned2018-02-09T11:29:35Z-
dc.date.available2018-02-09T11:29:35Z-
dc.date.issued2012-08-14-
dc.identifier.citationZita Carvalho-Santos, Pedro Machado, Inês Alvarez-Martins, Susana M. Gouveia, Swadhin C. Jana, Paulo Duarte, Tiago Amado, Pedro Branco, Micael C. Freitas, Sara T.N. Silva, Claude Antony, Tiago M. Bandeiras, Mónica Bettencourt-Dias, BLD10/CEP135 Is a Microtubule-Associated Protein that Controls the Formation of the Flagellum Central Microtubule Pair, Developmental Cell, Volume 23, Issue 2, 2012, Pages 412-424, ISSN 1534-5807, https://doi.org/10.1016/j.devcel.2012.06.001. (http://www.sciencedirect.com/science/article/pii/S1534580712002511)pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.7/835-
dc.descriptionThe deposited article is a post-print version and has been submitted to peer review.pt_PT
dc.descriptionThe deposited article is a pre-print versionpt_PT
dc.descriptionThis deposit is composed by the main article and the supplementary materials are present in the publisher's page in the following link: https://ars.els-cdn.com/content/image/1-s2.0-S1534580712002511-mmc1.pdfpt_PT
dc.description.abstractCilia and flagella are involved in a variety of processes and human diseases, including ciliopathies and sterility. Their motility is often controlled by a central microtubule (MT) pair localized within the ciliary MT-based skeleton, the axoneme. We characterized the formation of the motility apparatus in detail in Drosophila spermatogenesis. We show that assembly of the central MT pair starts prior to the meiotic divisions, with nucleation of a singlet MT within the basal body of a small cilium, and that the second MT of the pair only assembles much later, upon flagella formation. BLD10/CEP135, a conserved player in centriole and flagella biogenesis, can bind and stabilize MTs and is required for the early steps of central MT pair formation. This work describes a genetically tractable system to study motile cilia formation and provides an explanation for BLD10/CEP135's role in assembling highly stable MT-based structures, such as motile axonemes and centrioles.pt_PT
dc.description.sponsorshipFundação para a Ciência e Tecnologia grants: (PTDC/BIA-BCM/105602/2008); EMBO Installation Grant; Instituto Gulbenkian de Ciência; EMBO YIP Program; European Research Council grant: ([FP7/2010]/ERC Grant “261344-CentrioleStructNumber.”); Ciência 2007; EMBO, Marie Curie Actions.pt_PT
dc.language.isoengpt_PT
dc.publisherElsevierpt_PT
dc.relationinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/105602/PTpt_PT
dc.relationinfo:eu-repo/grantAgreement/EC/FP7/261344/EUpt_PT
dc.rightsopenAccesspt_PT
dc.subjectAnimalspt_PT
dc.subjectDrosophila Proteinspt_PT
dc.subjectDrosophila melanogasterpt_PT
dc.subjectFlagellapt_PT
dc.subjectMalept_PT
dc.subjectMicroscopy, Electron, Transmissionpt_PT
dc.subjectMicrotubule-Associated Proteinspt_PT
dc.subjectMicrotubulespt_PT
dc.subjectProtein Bindingpt_PT
dc.subjectSpermatogenesispt_PT
dc.subjectCiliapt_PT
dc.titleBLD10/CEP135 Is a Microtubule-Associated Protein that Controls the Formation of the Flagellum Central Microtubule Pairpt_PT
dc.typearticlept_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
degois.publication.firstPage412pt_PT
degois.publication.issue2pt_PT
degois.publication.lastPage424pt_PT
degois.publication.titleDevelopmental Cellpt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S1534580712002511?via%3Dihubpt_PT
dc.peerreviewedyespt_PT
degois.publication.volume23pt_PT
dc.identifier.doi10.1016/j.devcel.2012.06.001pt_PT
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