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Title: Plasticity of TH17 cells in Peyer's patches is responsible for the induction of T cell–dependent IgA responses
Author: Hirota, Keiji
Turner, Jan-Eric
Villa, Matteo
Duarte, João H
Demengeot, Jocelyne
Steinmetz, Oliver M
Stockinger, Brigitta
Keywords: Antibodies
Mucosal immunology
T-helper 17 cells
Issue Date: 10-Mar-2013
Publisher: Nature Publishing Group
Citation: Nature Immunology volume 14, pages 372–379 (2013)
Abstract: Intestinal Peyer's patches are essential lymphoid organs for the generation of T cell-dependent immunoglobulin A (IgA) for gut homeostasis. Through the use of interleukin 17 (IL-17) fate-reporter mice, we found here that endogenous cells of the TH17 subset of helper T cells in lymphoid organs of naive mice 'preferentially' homed to the intestines and were maintained independently of IL-23. In Peyer's patches, such TH17 cells acquired a follicular helper T cell (TFH cell) phenotype and induced the development of IgA-producing germinal center B cells. Mice deficient in TH17 cells failed to generate antigen-specific IgA responses, which provides evidence that TH17 cells are the crucial subset required for the production of high-affinity T cell-dependent IgA.
Description: This deposit is composed by a publication in which the IGC's authors have had the role of collaboration (it's a collaboration publication). This type of deposit in ARCA is in restrictedAccess (it can't be in open access to the public), and can only be accessed by two ways: either by requesting a legal copy from the author (the email contact present in this deposit) or by visiting the following link:
Peer review: yes
DOI: 10.1038/ni.2552
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Appears in Collections:LP - Artigos

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