Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.7/892
Título: CANA: A python package for quantifying control and canalization in Boolean Networks
Autor: Correia, Rion Brattig
Gates, Alexander J.
Wang, Xuan
Rocha, Luis M.
Palavras-chave: Boolean networks
python package
biochemical regulation
logical modeling
network dynamics
complex systems
Data: 14-Ago-2018
Editora: Frontiers Media
Citação: Correia RB, Gates AJ, Wang X and Rocha LM (2018) CANA: A Python Package for Quantifying Control and Canalization in Boolean Networks. Front. Physiol. 9:1046. doi: 10.3389/fphys.2018.01046
Resumo: Logical models offer a simple but powerful means to understand the complex dynamics of biochemical regulation, without the need to estimate kinetic parameters. However, even simple automata components can lead to collective dynamics that are computationally intractable when aggregated into networks. In previous work we demonstrated that automata network models of biochemical regulation are highly canalizing, whereby many variable states and their groupings are redundant (Marques-Pita and Rocha, 2013). The precise charting and measurement of such canalization simplifies these models, making even very large networks amenable to analysis. Moreover, canalization plays an important role in the control, robustness, modularity and criticality of Boolean network dynamics, especially those used to model biochemical regulation (Gates and Rocha, 2016; Gates et al., 2016; Manicka, 2017). Here we describe a new publicly-available Python package that provides the necessary tools to extract, measure, and visualize canalizing redundancy present in Boolean network models. It extracts the pathways most effective in controlling dynamics in these models, including their effective graph and dynamics canalizing map, as well as other tools to uncover minimum sets of control variables.
Descrição: This deposit is composed by the main article. The supplementary materials can be accessed through the following link: github.com/rionbr/CANA
Peer review: yes
URI: http://hdl.handle.net/10400.7/892
DOI: 10.3389/fphys.2018.01046
Versão do Editor: https://www.frontiersin.org/articles/10.3389/fphys.2018.01046/full#h9
Aparece nas colecções:CASCB- Artigos

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