Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.7/898
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dc.contributor.authorLafuente, Elvira-
dc.contributor.authorDuneau, David-
dc.contributor.authorBeldade, Patrícia-
dc.date.accessioned2018-10-10T11:50:16Z-
dc.date.available2018-10-10T11:50:16Z-
dc.date.issued2018-09-26-
dc.identifier.citationLafuente E, Duneau D, Beldade P (2018) Genetic basis of thermal plasticity variation in Drosophila melanogaster body size. PLoS Genet 14(9): e1007686. https://doi.org/10.1371/journal. pgen.1007686pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.7/898-
dc.descriptionThis deposit is composed by the main article. The supplementary materials can be found on-line through the following link: https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1007686#sec017pt_PT
dc.description.abstractBody size is a quantitative trait that is closely associated to fitness and under the control of both genetic and environmental factors. While developmental plasticity for this and other traits is heritable and under selection, little is known about the genetic basis for variation in plasticity that can provide the raw material for its evolution. We quantified genetic variation for body size plasticity in Drosophila melanogaster by measuring thorax and abdomen length of females reared at two temperatures from a panel representing naturally segregating alleles, the Drosophila Genetic Reference Panel (DGRP). We found variation between genotypes for the levels and direction of thermal plasticity in size of both body parts. We then used a Genome-Wide Association Study (GWAS) approach to unravel the genetic basis of inter-genotype variation in body size plasticity, and used different approaches to validate selected QTLs and to explore potential pleiotropic effects. We found mostly "private QTLs", with little overlap between the candidate loci underlying variation in plasticity for thorax versus abdomen size, for different properties of the plastic response, and for size versus size plasticity. We also found that the putative functions of plasticity QTLs were diverse and that alleles for higher plasticity were found at lower frequencies in the target population. Importantly, a number of our plasticity QTLs have been targets of selection in other populations. Our data sheds light onto the genetic basis of inter-genotype variation in size plasticity that is necessary for its evolution.pt_PT
dc.description.sponsorshipFinancial support for this work was provided by the Portuguese science funding agency, Fundação para a Ciência e Tecnologia, FCT: PhD fellowship to EL (SFRH/BD/52171/2013), and research grant to PB (PTDC/BIA-EVF/0017/2014); French research funding agency, Agence Nationale de la Recherche, ANR: Laboratory of Excellence TULIP, ANR-10-LABX-41 and ANR-11-IDEX-0002-02 (support for DD and PB) and French research centre, Centre National de la Recherche Scientifique, CNRS: International Associated Laboratory, LIA BEEG-B (support for DD and PB), and the People Programme (Marie Curie Actions) of the European Union's Seventh Framework Programme (FP7/2007-2013) under REA grant agreement (PCOFUND-GA-2013-609102), through the PRESTIGE programme coordinated by Campus France (support for DD). This work was developed with the support of the research infrastructure Congento, project LISBOA 01-0145-FEDER-022170, co-financed by Lisboa Regional Operational Programme (Lisboa 2020), under the Portugal 2020 Partnership Agreement, through the European Regional Development Fund (ERDF), and Foundation for Science and Technology (FCT,Portugal). The funders had no role in study design,data collection and analysis, decision to publish, or preparation of the manuscript.pt_PT
dc.language.isoengpt_PT
dc.publisherPublic Library of Sciencept_PT
dc.relationinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F52171%2F2013/PTpt_PT
dc.relationPTDC/BIA-EVF/0017/2014pt_PT
dc.relationANR-10-LABX-41pt_PT
dc.relationANR-11- IDEX-0002-02pt_PT
dc.relationinfo:eu-repo/grantAgreement/EC/FP7/609102/EUpt_PT
dc.relationLISBOA-01-0145-FEDER- 022170pt_PT
dc.rightsopenAccesspt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectGenome-wide association studiespt_PT
dc.subjectQuantitative trait locipt_PT
dc.subjectAbdomenpt_PT
dc.subjectPhysiological parameterspt_PT
dc.subjectThoraxpt_PT
dc.subjectGenetic polymorphismpt_PT
dc.subjectMolecular geneticspt_PT
dc.subjectDrosophila melanogasterpt_PT
dc.titleGenetic basis of thermal plasticity variation in Drosophila melanogaster body sizept_PT
dc.typearticlept_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
degois.publication.firstPage1pt_PT
degois.publication.issue9pt_PT
degois.publication.lastPage24pt_PT
degois.publication.titlePLoS Geneticspt_PT
dc.relation.publisherversionhttps://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1007686pt_PT
dc.peerreviewedyespt_PT
degois.publication.volume14pt_PT
dc.identifier.doi10.1371/journal.pgen.1007686pt_PT
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