Maric-Biresev, JelenaHunn, Julia P.Krut, OlegHelms, J. BerndMartens, SaschaHoward, Jonathan C.2016-04-262016-04-262016-04-20Maric-Biresev, J., Hunn, J. P., Krut, O., Helms, J. B., Martens, S., Howard, J. C. (2016). Loss of the interferon-γ-inducible regulatory immunity-related GTPase (IRG), Irgm1, causes activation of effector IRG proteins on lysosomes, damaging lysosomal function and predicting the dramatic susceptibility of Irgm1-deficient mice to infection. BMC Biology, 14, 33.http://hdl.handle.net/10400.7/581The interferon-γ (IFN-γ)-inducible immunity-related GTPase (IRG), Irgm1, plays an essential role in restraining activation of the IRG pathogen resistance system. However, the loss of Irgm1 in mice also causes a dramatic but unexplained susceptibility phenotype upon infection with a variety of pathogens, including many not normally controlled by the IRG system. This phenotype is associated with lymphopenia, hemopoietic collapse, and death of the mouse.engImmunity-related GTPasesIRGsPathogen recognitionIrgm1Irgm3LysosomesAutophagyjournal article10.1186/s12915-016-0255-4