Gordo, I.Dionisio, F.2010-03-252010-03-252005-03-18Gordo, I., Dionisio, F. (2005). Nonequilibrium model for estimating parameters of deleterious mutations. Phys. Rev. E. 71(3), 031907ISSN: 1539-3755http://hdl.handle.net/10400.7/91Deleterious mutations are of extreme evolutionary importance because, even though they are eliminated by natural selection, their continuous pressure creates a pool of variability in natural populations. They are of potential relevance for the existence of several features in evolution, such as sexual reproduction, and pose a risk to small asexual populations. Despite their extreme importance, the deleterious mutation rate and the effects of each mutation on fitness are poorly known quantities. Here we analyze a simple model that can be applied to simple experiments, in microorganisms, aiming at the quantification of these values.engEvolutionGenetic Variation/geneticsGenetics, Population/methodsModels, GeneticMutation/geneticsPopulation DynamicsSelection, Geneticjournal article10.1103/PhysRevE.71.031907