Moreira, SusanaRodrigues, RaquelBarros, André B.Pejanovic, NadjaNeves-Costa, AnaPedroso, DoraPereira, CláudiaFernandes, DinaRodrigues, João ValençaBarbara, CristinaMoita, Luís Ferreira2017-12-052017-12-052017-11-06Moreira S, Rodrigues R, Barros AB, Pejanovic N, Neves-Costa A, Pedroso D, Pereira C, Fernandes D, Rodrigues JV, Barbara C and Moita LF (2017) Changes in Expression of the CLOCK Gene in Obstructive Sleep Apnea Syndrome Patients Are Not Reverted by Continuous Positive Airway Pressure Treatment. Front. Med. 4:187. doi: 10.3389/fmed.2017.00187http://hdl.handle.net/10400.7/814This deposit is composed by the main article plus the supplementary materials of the publication.Metabolic syndrome and cardiovascular disease are strongly associated with obstructive sleep apnea syndrome (OSAS), which causes substantial changes to normal circadian physiological functions, including metabolic pathways. Because core clock genes are known to be modulated by sleep/vigilance cycles, we asked whether the expression level of mRNA coding for clock genes is altered in non-treated OSAS patients and if it can be corrected by standard continuous positive airway pressure (CPAP) treatment.engobstructive sleep apnea syndromeclock genescontinuous positive airway pressureslow wave sleepMetabolic SyndromeCircadian Rhythmsjournal article10.3389/fmed.2017.00187