Fesel, C.Goulart, L.F.Neto, A.S.Coelho, A.Fontes, C.J.F.Braga, E.M.Vaz, N.M.2011-05-192011-05-192005-01Fesel, C., L. F. Goulart, A. S. Neto, A. Coelho, C. J. F. Fontes, E. M. Braga and N. M. Vaz (2005). "Increased polyclonal immunoglobulin reactivity toward human and bacterial proteins is associated with clinical protection in human Plasmodium infection." Malaria Journal 4:51475-2875http://hdl.handle.net/10400.7/216http://dx.doi.org/10.1186/1475-2875-4-5The observed difference in polyclonal antibody production seems related to intrinsic activation states of infected individuals, rather than to parasite-antigen specific immune responses. However, it appears influenced by preceding stimuli. This supports the idea that acquired clinical immunity may not exclusively depend on antigen-specific responses, but also on the individual polyclonal reaction.engImmunity, Innate/immunologyImmunoglobulin G/bloodImmunoglobulin G/immunologyMalaria, Falciparum/epidemiologyMalaria, Falciparum/immunologyMalaria, Vivax/epidemiologyMalaria, Vivax/immunologyEscherichia coli Proteins/immunologyjournal article