Badenes, MarinaAdrain, Colin2020-05-012020-05-012019http://hdl.handle.net/10400.7/956iRhom2 is an essential cofactor for ADAM17, the metalloprotease that sheds both the proinflammatory cytokine tumor necrosis factor-α (TNF-α) and TNF receptors (TNFRs) from the cell surface. In this issue of Science Signaling, Sundaram et al. demonstrate a protective role for iRhom2 in promoting ADAM17-mediated shedding of TNFRs in hepatic stellate cells, which reduces TNFR signaling and liver fibrosis in response to injury.engiRhom2; ADAM17TNFjournal article10.1126/scisignal.aaz0444