Parada, EstherEgea, JavierBuendia, IzaskunNegredo, PilarCunha, Ana C.Cardoso, SilviaSoares, Miguel P.López, Manuela G.2017-06-222017-06-222013-09-26Esther Parada, Javier Egea, Izaskun Buendia, Pilar Negredo, Ana C. Cunha, Silvia Cardoso, Miguel P. Soares, and Manuela G. López. Antioxidants & Redox Signaling. September 2013, 19(11): 1135-1148. https://doi.org/10.1089/ars.2012.4671http://hdl.handle.net/10400.7/772The deposited article is a post-print version.This deposit is composed by the main article, and it hasn't any supplementary materials associated.This publication hasn't any creative commons license associated.We asked whether the neuroprotective effect of cholinergic microglial stimulation during an ischemic event acts via a mechanism involving the activation of nuclear factor erythroid-2-related factor 2 (Nrf2) and/or the expression of its target cytoprotective gene, heme oxygenase-1 (HO-1). Specifically, the protective effect of the pharmacologic alpha-7 nicotinic acetylcholine receptor (α7 nAChR) agonist PNU282987 was analyzed in organotypic hippocampal cultures (OHCs) subjected to oxygen and glucose deprivation (OGD) in vitro as well as in photothrombotic stroke in vivo.engAnimalsAnti-Inflammatory AgentsAntioxidantsCell DeathCell SurvivalCerebral InfarctionCultural DeprivationHeme Oxygenase-1HippocampusMiceMice, TransgenicMicrogliaNF-E2-Related Factor 2Neuroprotective AgentsNicotinic AgonistsOrgan Culture TechniquesOxidative StressRatsReactive Oxygen SpeciesSignal TransductionTumor Necrosis Factor-alphaalpha7 Nicotinic Acetylcholine Receptorjournal article10.1089/ars.2012.4671