Bergman, Marie-LouiseLopes-Carvalho, ThiagoMartins, Ana-CatarinaGrieco, Fabio A.Eizirik, Décio L.Demengeot, Jocelyne2017-12-112017-12-112017-05-23Tolerogenic insulin peptide therapy precipitates type 1 diabetes Marie-Louise Bergman, Thiago Lopes-Carvalho, Ana-Catarina Martins, Fabio A. Grieco, Décio L. Eizirik, Jocelyne Demengeot Journal of Experimental Medicine Jul 2017, 214 (7) 2153-2156; DOI: 10.1084/jem.20160471http://hdl.handle.net/10400.7/820The deposited article version contains attached the supplementary materials within the pdf.Daniel et al. (https://doi.org/10.1084/jem.20110574) have previously published in JEM a study on the preventive effect of tolerogenic vaccination with a strong agonist insulin mimetope in type 1 diabetes. Our study now challenges these results and shows that osmotic pump delivery of the modified insulin peptide R22E did not prevent hyperglycemia, accelerated disease onset, increased its incidence, and worsened insulitis.porAnimalsAutoantibodiesDiabetes Mellitus, Type 1FemaleHyperglycemiaInsulinInsulin AntibodiesMice, Inbred NODMicroscopy, FluorescenceVaccinationEpitopesAutoimmunityjournal article10.1084/jem.20160471